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TLR-induced inflammasome priming triggers IL-1β and NLRP3 ubiquitylation.para que sirve el bactrim 800 E2 conjugating enzyme UbcH5a and E3 ubiquitin ligase cellular IAP1 (cIAP1), and the conjugation of ubiquitin onto FLAG-IL-1β analyzed by immunoblot. One of three experiments. ns, non-specific band. Credit: <i>Nature Communications</i> (2021). DOI: 10.1038/s41467-021-22979-3″ width=”800″ height=”529″>

Chronic or acute inflammation can contribute to a range of ailments—some potentially deadly—including stroke, respiratory and heart disease, cancer, arthritis, asthma, dementia, multiple sclerosis, and diabetes. In May, a study by Dr. Kate Lawlor and collaborator Professor Vince James (WEHI) published in Nature Communications shed light on the potential triggers of inflammation.

The research focused on the cytokine, interleukin-1ß (IL-1ß), which is critical to clearing infections but is also associated with sepsis and driving autoinflammatory and inflammatory diseases including rheumatoid arthritis, type 2 diabetes, and atherosclerosis.

Previous IL-1ß research had focused on understanding how it is triggered and how inhibiting this process or neutralizing IL-1ß could reduce inflammation. However, little was known about how the precursor IL-1ß protein is regulated.

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