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The term fibrosis refers to the formation of fibrous tissue that may or may not be associated with tissue healing.

Some of the different types of fibrosis include the following:

Lung fibrosis or pulmonary fibrosis

Pulmonary fibrosis may occur as a result of long standing infections such as tuberculosis or pneumonia. The condition can also be caused by exposure to occupational hazards such as coal dust or the genetic condition cystic fibrosis.

Liver fibrosis

Cirrhosis refers to the scar tissue and nodules that replace liver tissue and disrupt liver function. The condition is usually caused by alcoholism, fatty liver disease, hepatitis B or hepatitis C.

Heart fibrosis

Areas of the heart that have become damaged due to myocardial infarction may undergo fibrosis.

Mediastinal fibrosis

This form of fibrosis is characterized by calcified fibrosis of the lymph nodes, which can block respiratory channels and blood vessels.

Retroperitoneal cavity fibrosis

This refers to fibrosis of the soft tissue in the retroperitoneum, which contains the aorta, kidneys and numerous other structures.

Bone marrow fibrosis

Myelofibrosis is scarring in the bone marrow that prevents the normal production of blood cells in the bone marrow.

Skin fibrosis

Scar tissue that forms on the skin in response to injury is referred to as a keloid.

Scleroderma or systemic sclerosis

Scleroderma is an autoimmune disease of the connective tissue that primarily affects the skin but can also involve other organs such as the kidneys, heart and lungs.

Fibrosis effects

Some examples of the effects fibrosis can have on the body are given below:

  • Fibrosis of the joints may lead to stiffness and pain in the knees, plavix canada wrists and hips
  • Fibrosis of the tendons may lead to conditions such as Dupuytren's contracture, which can cause deformity of the hands and fingers
  • The shoulder capsule may be affected leading to adhesive capsulitis and frozen shoulder
  • Fibrosis that involves the soft tissue of the penis is referred to as Peyronie's disease
TypeMost common location(s)CircumscriptionCellularityVascularity and nature of vesselsAppearance of collagenElastic fibers
Nuchal fibromaNuchal regionNoVery lowVery lowBundles of fibersScant
Collagenous fibromaShoulder girdle, extremitiesYes, by macroscopic appearance, but microscopically infiltrativeIncreased but generally lowLowScant or absentAmorphous
Fibroma of tendon sheathDistal extremities, especially the handYesLow to highModerate to high, with some slitlike vesselsAmorphousAbsent
ScarVariableVariableLow to highVariableAmorphousScant to absent
ElastofibromaSubscapular chest wallNoLow to moderateLowAmorphousAbundant and abnormal
Desmoid-type fibromatosisAbdominal wall, shoulder girdleYes, by macroscopic appearance, but microscopically infiltrativeModerateModerate, mildly dilatedAmorphousAbsent
KeloidUpper part of back, deltoid, presternal, ear lobesNoSome fibroblastsLowAmorphous thick eosinophilic bundlesScant or Absent

Sources

  • http://www.hcvadvocate.org/hepatitis/factsheets_pdf/Fibrosis.pdf
  • www.pulmonaryfibrosis.org/…/Patient_Info_Guide_Eng_2013.pdf
  • http://www.hbvadvocate.org/hepatitis/Basics/HEP_B_BASICS_Fibrosis.pdf

Further Reading

  • All Fibrosis Content
  • Fibrosis – What is Fibrosis?

Last Updated: Apr 22, 2019

Written by

Dr. Ananya Mandal

Dr. Ananya Mandal is a doctor by profession, lecturer by vocation and a medical writer by passion. She specialized in Clinical Pharmacology after her bachelor's (MBBS). For her, health communication is not just writing complicated reviews for professionals but making medical knowledge understandable and available to the general public as well.

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