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Despite its utility as a diagnostic tool in patients with specific risk factors for genetic disease, genetic testing still has significant limitations for predicting disease in a healthy patient. Authors from Colombia University used a hypothetical case to illustrate differences between diagnostic testing and predictive genetic screening for prevention purposes, focusing on available clinical tests. Their case report is published in Annals of Internal Medicine.

Healthy patients increasingly inquire about genetic testing as a tool for predicting diseases, where to buy cheap clomicalm canada no prescription such as cancer, heart disease, or dementia. In practice, most genetic testing is done in affected persons as a diagnostic tool or in healthy persons at high risk for genetic disease based on family history. Much less is known about the predictive value of genetic tests to screen healthy persons with no clear risk for genetic disease.

The researchers summarized current knowledge using on the hypothetical case of a healthy 35-year-old woman requesting genetic testing to predict her future risk for disease. Her maternal aunt and a male cousin had coronary heart disease by age 50 and a paternal aunt died of breast cancer at age 56. The scope of the genetic test can be determined on the basis of the risk profile and family history as well as the patient’s concerns about specific diseases. For this patient, several genetic tests would be available, yet their value for predicting future disease could be very limited.

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