Coronavirus Outcomes Range From Pandemic to a New Flu, Experts Say

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It’s already spread wider than SARS in 2003. It may not sweep the globe as swine flu did in 2009, but is more dangerous. It doesn’t kill at anywhere near the terrifying pace of Ebola in 2014, but it can be passed through the air.

Even as the number of new coronavirus cases in China appears to ebb, experts say they’re preparing for a future with a disease that past pandemics have only hinted at.

China’s lockdown of Hubei province, where the outbreak began, gave the worldseveral weeks to throw up its defenses, global health officials said Tuesday. But it hasn’t stopped the virus, with new cases popping up around the globe, potentially seeding a pandemic to come.

“Every virus is different,” said University of Michigan medical historian Howard Markel, who has studied influenza epidemics. “If anything the study of past epidemics has taught me is that anyone who predicts the future based on that is either a fool or lying because we don’t know.”

The virus has brought together elements that scare public health experts as well as average citizens. In less than three months, it’s infected tens of thousands of people. Humans have never faced it, leaving their immune systems vulnerable. And there are no vaccines to prevent 2019-nCoV, as the virus is called, or to treat the disease it causes, Covid-2019.

One certainty is that new cases will continue to emerge. On Saturday, an American passenger from a cruise ship that docked in Cambodia tested positive for the virus. It raised new worries that disembarked passengers from the boat, previously thought to be virus-free, would seed new pockets of disease.

The U.S. Centers for Disease Control and Prevention said last week that it will begin screening patients with flu symptoms for 2019-nCoV in five major U.S. cities. The effort is meant to detect whether the virus has slipped into the U.S. despite robust travel screening and quarantines that have caught the less-than-20 American cases identified so far.

The aspects the new coronavirus does share with other outbreaks are mostly human failures, not biological advantages.

In 1892, authorities in Hamburg, Germany—worried about impact cholera would have on their thriving port—initially kept quiet about some cases, allowing the disease to spread, said Markel. More than 8,000 eventually died in the city. And the disease soon arrived in New York. In Wuhan, local Chinese officials have been accused of minimizing the threat from the virus in the early weeks, when it could have been more easily stopped.

Willingness to endure economic disruption is another factor, said Markel. Epidemics are always enormously costly. Stopping trade and movement can slow a disease’s spread, but grind economies to a halt.

In a study published this month, the Chinese Center for Disease Control and Prevention warned that even with new infections in decline, they could rise again as the economy restarts, after an extension of the national Lunar New Year holiday and shutdowns of workplaces and public gathering spaces.

“Huge numbers of people will soon be returning to work and school,” a group of researchers at the Chinese agency wrote in their analysis. “We need to prepare for a possible rebound of the Covid-19 epidemic in the coming weeks.”

On the virus biology side, researchers still don’t know many basic parameters. One of the most crucial unknowns is whether the virus can spread when people aren’t showing symptoms. If a large fraction of people can catch and transmit the virus before becoming seriously ill, the odds of halting it with existing measures plummet, according to computer simulations run by the London School of Hygiene & Tropical Medicine.

“This virus has a firm foothold,” said Steven Riley, professor of infectious disease dynamics at Imperial College London’s MRC Centre for Global Infectious Disease Analysis. “There are many more people with it than there ever was with SARS. We don’t want this virus to become an established human pathogen. If it takes off in other parts of the world and remains a relatively severe virus, it would become a new kind of thing.”

The world should get a better view of how significant the outbreak will be in the next few weeks, as additional surveillance gives clearer insights into the virus’s spread by mid-March, said Michael Osterholm, an expert on infectious diseases at the University of Minnesota.

“We are just getting started,” he said. “If this spreads around the world, this will be just south of the 1918 pandemic,” he said, referring to the pandemic flu that killed millions a century ago. “The next three weeks are going to be critical.”

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